CFB Picks, 2025 Week 5

by
Bracket Yard
September 24, 2025

The CFB picks for Week 5 in 2025 will hopefully continue some forward momentum for Bracket Yard.

Week 4 was a good one for us, getting nine out of the ten games right overall, while going 7-3 in picks against the spread. Pretty respectable, but there is much more season to go.

As we do every single week, we have curated a list of 10 games out of the 53 FBS contests on the schedule. We will pick all games against the spread and straight-up; no over-under this season.

Before the Magic Begins

Important: Please remember that any selections herein are for entertainment purposes only. We are not affiliated with any gambling operation or professional team, nor are we encouraging you to do anything with these opinions. Please consult Bracket Yard’s Notice to Visitors for further clarification.

Game (Fav.)	Date/Time (ET)	S/U Pick	ATS Pick
TCU @ Arizona State (-2.5)	Friday 9:00pm	Arizona State	ASU -2.5
USC (-6.5) @ Illinois	Sat 12:00pm	USC	USC -6.5
Louisville (-4.5) @ Pittsburgh	Sat 12:00pm	Louisville	Louisville -4.5
LSU @ Ole Miss (-1.5)	Sat 3:30pm	LSU	LSU +1.5
Ohio State (-8) @ Washington	Sat 3:30pm	Ohio State	Ohio State -8
Auburn @ Texas A&M (-6.5)	Sat 3:30pm	Texas A&M	Texas A&M -6.5
Indiana (-7.5) @ Iowa	Sat 3:30pm	Indiana	Iowa +7.5
Arizona @ Iowa State (-6)	Sat 7:00pm	Iowa State	Iowa State -6
Oregon @ Penn State (-3.5)	Sat 7:30pm	Penn State	Penn State -3.5
Alabama @ Georgia (-3)	Sat 7:30pm	Alabama	Alabama +3

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College Football

CFB Picks, 2025 Week 5

CFB Picks, 2025 Week 5

Before the Magic Begins