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CFB Picks, 2025 Week 10

CFB Picks, 2025 Week 10

We are getting some non-power conferences involved in the CFB picks for Week 10 of the 2025 season.

Not all of the big games are in the major conferences, after all. Furthermore, at least one of the teams in the so-called “Group of 5” conferences is going to make the College Football Playoff. Will it be Boise State? Perhaps Memphis? Maybe even the Midshipmen of the US Naval Academy? That is still to be determined, but a few of their games are of importance this weekend.

As a result, we have added four games from the smaller conferences to the list. There are still six others from the power conferences that you know and (maybe) love. Bracket Yard picks our 10 games of the week against-the-spread and straight-up.

This has been a somewhat strange year. Some unexpected teams have risen to the top of FBS, while several premier programs are in the midst of down seasons. Picking the games has not been easy, that’s for sure.

What You Need to Know First

Any picks, predictions, and/or selections herein are for entertainment purposes only. We are not affiliated with any gambling operation or professional team, nor are we encouraging you to do anything with these opinions. Please consult Bracket Yard’s Notice to Visitors for further clarification on this matter.

Please also note that some of the spreads below may not match the spreads given in our preview video for the week. The below may be based on more recent information.

CFB Picks, 2025 Week 10: S/U and ATS

Game (Fav.)Date/Time (ET)S/U PickATS Pick
Memphis (-13.5) @ RiceSat 7:00pmMemphisMemphis -13.5
Vanderbilt @ Texas (-2.5)Sat 12:00pmVanderbiltVanderbilt +2.5
Miami (-12.5) @ SMUSat 12:00pmMiamiSMU +12.5
Navy @ North Texas (-6.5)Sat 12:00pmNorth TexasNavy +6.5
New Mexico @ UNLV (-3.5)Sat 3:00pmUNLVUNLV -3.5
Georgia (-7.5) vs. FloridaSat 3:30pmGeorgiaGeorgia -7.5
Fresno State @ Boise State (-17.5)Sat 3:30pmBoise StateBoise State -17.5
Oklahoma @ Tennessee (-3.5)Sat 7:30pmTennesseeTennessee -3.5
USC (-6.5) @ NebraskaSat 7:30pmUSCNebraska +6.5
Cincinnati @ Utah (-10.5)Sat 10:15pmUtahCincinnati +10.5

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