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CFB Picks, 2025 Week 2

CFB Picks, 2025 Week 2

The CFB picks for 2025 Week 2 are here, and at least now, we’ve seen these teams play.

Making picks for Week 0 or Week 1 in any level of football is difficult, but especially in college. After all, we have not seen the teams play, so you are making your picks guided by how they look on paper. For example, a lot of us thought Alabama was good, and nobody quite knew what to expect from Florida State after taking the year off in 2024. Going into Week 2, we have some basis for understanding what each team brings to the table – or what they do not. “Frame of reference” is the phrase of the week here.

As established last week, we have selected 10 games for our picks in Week 2.

Important: Please remember that any selections herein are for entertainment purposes only. We are not affiliated with any gambling operation or professional team, nor are we encouraging you to do anything with these opinions. Please consult Bracket Yard’s Notice to Visitors for further clarification.

Picks Standings: 2025 Season through Week 1

CFB Picks, 2025 Week 2

Game (Fav.)Date/Time (ET)S/U PickATS Pick
Illinois (-2.5) @ DukeSat 12pmIllinoisIllinois -2.5
Iowa @ Iowa State (-3.5)Sat 12pmIowa StateIowa State -3.5
Baylor @ SMU (-2.5)Sat 12pmSMUSMU -2.5
Oklahoma State @ Oregon (-28.5)Sat 3:30pmOregonOK State +28.5
Ole Miss (-10.5) @ KentuckySat 3:30pmOle MissMiss -10.5
Kansas @ Missouri (-6.5)Sat 3:30pmMissouriKansas +6.5
Arizona State (-6.5) @ Mississippi StateSat 7:30pmArizona StateArizona State -6.5
Michigan @ Oklahoma (-5.5)Sat 7:30pmMichiganMichigan +5.5
Boston College @ Michigan State (-4.5)Sat 7:30pmBoston CollegeBoston College +4.5
San Diego State (-1.5) @ Washington StateSat 10:15pmSan Diego StateSDSU -1.5

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